Vampire Diaries spoilers on Vicky and the next supernatural creature on series.
The minx of Mystic Falls is no more - though there is a chance we could see Vicky again. Kevin Williamson keeps mentioning that I will possibly be back in a dream or as a ghost.
Witches and vampires aren't the only supernatural creatures in Mystic Falls. It won't be right away, but a major male character will reveal himself to be a werewolf. And don't think having read the books will help you figure this one out. In fact, the werewolf in question won't even know he's a werewolf, initially at least.
Update: It's eaither Jeremy Gilbert or Matt Donovan.