Supernatural never shies away from death, and according to EW's Ausiello, we can expect more of it soon. In this week's Ask Ausiello column, he said a "somewhat pivotal" character will die soon.
My money's on Anna. The wayward angel makes her return in the upcoming episode "Back to the Future, Part II," in which Sam and Dean have to prevent her from killing their parents. I wouldn't be surprised if she ends up dying in the melee. Some chatter out there is that it will be Zachariah. I've also heard Bobby or Castiel, but I would consider them major characters, not simply "somewhat pivotal."
Nope, I'm thinking Anna. What do you think? Give your opinion in the comments below!