TV Line reports that the show has not forgotten about the effects of Gadreel's little stint inside Sam. Spoils EP Jeremy Carver: “We’re not done talking about it. There are more layers to it that are going to take a little while for even Sam to understand.”
As for Castiel? Carver teases that the stolen grace that Castiel used to become an angel again “is an issue which will not go undealt with.”
And will Jensen get the chance to direct again next season? Absolutely, says the man himself to EOnline:
Yes, I did kind of throw the phone call out recently. Last year, I was busy being a new dad, so this year I hopefully…well, actually I don't have more time on my hands, but I'm gonna attempt to try it again, so yeah, I think I will try it again."