Well, not as family. Though I guess Mitchell's ex and Luke and Manny's school janitor could be considered family. If you stretch it.
As reported by TV Guide, 24's Mary Lynn Rajskub and Machete's Danny Trejo will be appearing in guest stints in upcoming (though I'm guessing separate) episodes - Rajskub as Mitchell's ex-high-school-girlfriend come for a visit (who wants to bet she and Cam end up as buddies?), and Trejo as the "scary" janitor Claire comes face-to-face with at Luke and Manny's school.
Who wants to agree on an awesome casting job with the latter?