More bad news for Huddy?

For a couple weeks we've been hearing murmurs of trouble brewing for House and Cuddy (you can find more spoilers on that here). Now after Greg Yaitanes' ominous tweet of "is next week the end of Huddy?" comes this quote from Katie Jacobs, given to TV Line's Michael Ausiello:

Question: I need Huddy news, please! [House producer/director] Greg Yaitanes issued an ominous Tweet that would seem to suggest the end is near. —Elizabeth
Ausiello: You thought that was ominous? Check out what EP Katie Jacobs recently told me about the couple’s future: “Maybe Huddy isn’t all that it’s cracked up to be. I think the exploration of the relationship is interesting. I don’t think the fans are expecting it to go on forever, are they?” She asks a good question: Are you expecting House and Cuddy to go the distance? And if not, how long do you give them?

What do you think is going to happen to Huddy?