- On the day of April's wedding, the Grey Sloan Memorial doctors are all preoccupied with their own drama.
- Meredith and Cristina continue to argue about their research and careers, Bailey comes clean to Ben about her feelings regarding him moving back to Seattle, and Shane puts himself in a risky situation.
- Meanwhile, Derek gets a phone call that will change his life, on the winter finale of "Grey's Anatomy".
"Grey's Anatomy" stars Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Justin Chambers as Alex Karev, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber, Sara Ramirez as Callie Torres, Kevin McKidd as Owen Hunt, Jessica Capshaw as Arizona Robbins, Jesse Williams as Jackson Avery, Sarah Drew as April Kepner, Camilla Luddington as Jo Wilson, Gaius Charles as Shane Ross, Jerrika Hinton as Stephanie Edwards and Tessa Ferrer as Leah Murphy.
Guest cast TBA.
"Get Up, Stand Up" was written by William Harper and directed by Tony Phelan.