Now that we know Katherine Heigl is for sure leaving, the big question is: how exactly is her departure going to be handled by the Grey's-powers-that-be? Well Ausiello's got the deets on how exactly Izzie's absence will be explained now that Katherine Heigl is no longer filming -- check it out!
Question: Will Grey’s Anatomy address Izzie’s whereabouts at all? Or are they just going to pretend she never existed now that Katherine Heigl isn’t returning? —Mickey
Ausiello: They’re definitely not going to pretend she never existed. In fact, I’m told the Izzie issue will be addressed during May sweeps. For her part, Katherine Heigl thinks her Jan. 21 farewell — while not originally intended to be her last episode — oddly works as a bookend to Izzie’s story. “Even though there’s a part of me that would like to go back and do the quick Izzie farewell,” she says, “I also think that my last scene — where Meredith says to Izzie, ‘Don’t go, we’re your family,’ and Izzie’s response was, ‘No you’re not, you’re just a bunch of people I worked with, and I can find that anywhere’ — was kind of tragic and appropriate all at the same time. When I was playing the scene I was really trying to convey that, for Izzie, that was a lie that she had to tell herself to have the courage to move on.”
Source: Ausiello Files