• Season 4 Episode 7
  • Physical Attraction... Chemical Reaction

  • Airdate:10.11.2007.

George and Izzie's romantic chemistry is put to the test, as Derek asks for more than a physical connection from Meredith; much to his own surprise, Mark develops a crush on a fellow surgeon, and Callie's role as Chief Resident is placed in jeopardy after she delegates much of her job to Bailey,

series regulars:

    Ellen Pompeo as Meredith Grey
    Patrick Dempsey as Derek Shepherd
    Sandra Oh as Cristina Yang
    Katherine Heigl as Isobel "Izzie" Stevens
    Justin Chambers as Alex Karev
    T.R. Knight as George O'Malley
    Chandra Wilson as Miranda Bailey
    James Pickens, Jr. as Richard Webber
    Sara Ramirez as Callie Torres
    Eric Dane as Mark Sloan
    Chyler Leigh as Lexie Grey.

guest cast:

    Jeff Perry as Thatcher
    Rockmond Dunbar as Sean
    Stephanie March as Jane
    Vicki Lewis as Harriet
    David Burke as Don
    Kurt Fuller as Jerry
    Enuka Okuma as Teresa.

directed by:

Jeff Melman