• Season 4 Episode 13
  • Piece of My Heart

  • Airdate:01.05.2008.

Addison returns to Seattle Grace to perform an operation and is taken aback by all of the changes in her old co-workers' lives. Meanwhile Meredith and Derek's clinical trial has its first patient, and Rebecca/Ava returns with shocking news for Alex 

series regulars:

    Ellen Pompeo as Meredith Grey
    Patrick Dempsey as Derek Shepherd
    Sandra Oh as Cristina Yang
    Katherine Heigl as Isobel "Izzie" Stevens
    Justin Chambers as Alex Karev
    T.R. Knight as George O'Malley
    Chandra Wilson as Miranda Bailey
    James Pickens, Jr. as Richard Webber
    Sara Ramirez as Callie Torres
    Eric Dane as Mark Sloan
    Chyler Leigh as Lexie Grey
    Brooke Smith as Erica Hahn

guest cast:

    Kate Walsh as Addison
    Amy Madigan as Dr. Wyatt
    Elizabeth Reaser as Rebecca
    Clea Duvall as Jennifer
    Lauren Stamile as Rose
    Kathleen Rose Perkins as Sarah
    Ken Barnett as Freddie
    Jason O'Mara as Phillip

written by:

Stacy McKee

directed by:

Mark Tinker