• Season 4 Episode 1
  • A Change is Gonna Come

  • Airdate:27.09.2007.

Having just returned from her honeymoon with Meredith, Cristina searches for Burke, but he's nowhere to be found. Meredith, Cristina, Izzie and Alex spend their first day as residents with their own groups of interns. Among the interns are George, repeating his intern year after failing his exams, and Lexie Grey, Meredith's half-sister whom she has never met. Now that Derek's relationship with Meredith has reached an emotional impasse, he looks to his fellow doctors for friendship; Bailey wrestles with her place within the hospital now that her former interns report to new Chief Resident Callie; and Richard resumes his position as Chief of Surgery.

series regulars:

    Ellen Pompeo as Meredith Grey
    Patrick Dempsey as Derek Shepherd
    Sandra Oh as Cristina Yang
    Katherine Heigl as Isobel "Izzie" Stevens
    Justin Chambers as Alex Karev
    T.R. Knight as George O'Malley
    Chandra Wilson as Miranda Bailey
    James Pickens, Jr. as Richard Webber
    Sara Ramirez as Callie Torres
    Eric Dane as Mark Sloan
    Chyler Leigh as Lexie Grey.

guest cast:

    Mark Pellegrino as Chris
    Sandra Thigpen as Clara
    Stephanie Childers as Nancy
    Steven M. Porter as Joey
    Candice Afia as Intern Laura
    Amrapali Ambegaokar as Intern Dani
    Tymberlee Chanel as Intern Claire
    Gloria Garayua as Intern Graziella
    Molly Kidder as Intern Megan
    Richard Keith as Intern Mitch
    Joy Osmanski as Intern Lucy
    Winston Story as Intern Leo
    Joseph Williamson as Intern Pierce

written by:

Shonda Rhimes

directed by:

Rob Corn