- Season 2 Episode 2
Enough Is Enough (No More Tears)
When a family arrives at Seattle Grace Hospital after a serious car accident, Alex learns that their injuries are only the beginning of their problems. Meanwhile, as Dr. Webber recovers from brain surgery, it seems that his wife (guest starring Loretta Devine as Mrs. Webber) has some concerns about the state of their marriage.
Ellen Pompeo as Meredith Grey
Patrick Dempsey as Derek Shepherd
Sandra Oh as Cristina Yang
Isaiah Washington as Preston Burke
Katherine Heigl as Isobel "Izzie" Stevens
Justin Chambers as Alex Karev
T.R. Knight as George O'Malley
Chandra Wilson as Miranda Bailey
James Pickens, Jr. as Richard Webber.
Loretta Devine as Mrs. Webber
Sarah Utterback as Nurse Olivia
Romy Rosemont as Lea Seibert
Lukas Behnken as Scott Seibert
Scott Michael Campbell as Mr. Hubble.