The nurses at Seattle Grace Hospital go on strike, leaving the doctors to fend for themselves; Meredith's mistake in treating an elderly patient is brought to light by the patient's friends (June Lockhart, Betty Garrett and Rae Allen) and Izzie treats a pregnant teen.
Ellen Pompeo as Meredith Grey
Patrick Dempsey as Derek Shepherd
Sandra Oh as Cristina Yang
Isaiah Washington as Preston Burke
Katherine Heigl as Isobel "Izzie" Stevens
Justin Chambers as Alex Karev
T.R. Knight as George O'Malley
Chandra Wilson as Miranda Bailey
James Pickens, Jr. as Richard Webber
Kate Walsh as Addison Shepherd
June Lockhart as Agnes
Betty Garrett as Eleanor
Rae Allen as Ruth.