- Season 2 Episode 13
Begin the Begin
Izzie seems to be getting over Alex when she shares an undeniable chemistry with Denny Duquette, a patient who's awaiting a heart transplant, and George treats Bex, a young teen hermaphrodite.
Ellen Pompeo as Meredith Grey
Patrick Dempsey as Derek Shepherd
Sandra Oh as Cristina Yang
Isaiah Washington as Preston Burke
Katherine Heigl as Isobel "Izzie" Stevens
Justin Chambers as Alex Karev
T.R. Knight as George O'Malley
Chandra Wilson as Miranda Bailey
James Pickens, Jr. as Richard Webber
Kate Walsh as Addison Shepherd
Jeffrey Dean Morgan as Denny Duquette
Becca Gardner as Bex.