- Season 1 Episode 7
The Self-Destruct Button
Derek and Meredith try (unsuccessfully) to be discreet as they spend the night together at Meredith's house, but their haggard appearance speaks volumes to everyone - including Bailey, who warns Meredith to end the relationship. Meanwhile George suspects an anesthesiologist of drinking on the job but is reluctant to speak up about it, Alex treats a former schoolmate who finds honor in self-mutilation, Izzie's boyfriend takes extreme measures in order for them to spend more time together, and Cristina seems to be battling a case of the flu,
Ellen Pompeo as Meredith Grey
Patrick Dempsey as Derek Shepherd
Sandra Oh as Cristina Yang
Isaiah Washington as Preston Burke
Katherine Heigl as Isobel "Izzie" Stevens
Justin Chambers as Alex Karev
T.R. Knight as George O'Malley
Chandra Wilson as Miranda Bailey
James Pickens, Jr. as Richard Webber.
Ever Carradine as Athena
Amanda Macdonald as Claire Rice
Kim Morgan Greene as Mrs. Rice
Russell Hornsby as Digby Owens.