Here's some spoilers that you Grey's Anatomy fans may love.. it'll answer the question: how will Callie & Mark hooking up affect a Calzona reunion? Check out the spoilers and see what you guys think!
Will Callie's hookup with Mark come back to haunt her when Arizona returns on Grey's Anatomy? — Sharlene
NATALIE: Here's the good news: "Callie and Arizona will be back together soon," executive producer Shonda Rhimes says simply, adding that Arizona will soon show up on Callie's doorstep. "[The breakup] was a way to jump-start the next phase of their storyline." The bad news? Oh wait, this is good news, too! "Mark is her best friend, they slept together before, so it's just recycling. Two people having sex does not necessarily mean that they're in love, or that they're going to be together, or that it means anything."
Source: TV Guide