So in "Sectionals", we discovered that Santana (Naya Rivers) might not be as evil as we all think. Turns out she actually enjoys the glee club, it's one of the highlights of her day. She wouldn't do anything to sabotage their competition chances.
Well, maybe she wouldn't do anything to sabotage the glee club, but I wouldn't count out even the members just yet...or even the rest of the school. According to Rivers, in the new episodes Santana will be back on the loose:
"Santana's been wreaking havoc with people's boyfriends and people's babies and teachers—she's the high school terror, and she's going to continue to be the villain."
Somehow, now I'm picturing Santana as Sue's eyes and ears even more, now that the villainous Cheerios' coach has been uprooted from her precious position. Perhaps she's part of that "destination: horror".