According to previous spoiler, either Susan, Gaby or Lynette will suffer a serious loss.
Well, it looks like it's gonna be Lynette who'll suffer this terrible loss after all.
Read this big spoiler from E!Online:
"Lynette is pregnant with twins; she loses one of them—they could save it—but it would be deformed or something. So, she loses one of the twins, that's what happens."
For a any other mother like Lynette who loves their children dearly, this must be really difficult. But over the past years, we've seen the strong sense of Lynette's character so, no doubt, she'll be able to handle this as well.