When season 5 of Brothers & Sisters opens, Holly is the last person that we are going to be getting any spoilers from. Holly will have suffered memory loss from the catastrophic events of the fourth season finale. The memory loss will be so severe she won't even remember her own daughter, Rebecca(Emily VanCamp). We won't see Rebecca until the third and fourth episode of the 5th season when VanCamp returns to wrap up her storyline. Word has it she and Justin will be having major problems.
If all that weren't enough, one of the Walker women wants to get pregnant!
Source: Watch With Kristin