Although Agents of SHIELD has wrapped up the Framework storyline in season 4's finale, there's still a chance that Marvel might revisit the alternate universe and turn it into a spinoff series down the line.
In a report from EW, exec producer Jed Whedon dropped this comment about the Framework's future:
The Framework opened up a lot of ideas and a lot of possibilities, and our head of post keeps reminding us of that, because he’s the biggest fan of the Framework, and he thinks it should be its own spinoff show.
As to whether the upcoming fifth season of Agents of SHIELD has ultimately shut its doors to the Framework, here's what EP Jeff Bell offered:
Everything we do is based on not wanting to repeat our selves.
We’re trying to tell different kinds of stories and show our characters in different situations. The last thing we want is for people to say, ‘Oh, they’re trotting that thing out again.’ If there were a way to tell a fresh story with something else to say, I think all storytelling is on the table.
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